TROPiCS-02 Sacituzumab Govitecan Effective in Hormone Receptor–Positive, HER2-Negative Metastatic Breast Cancer
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TROPiCS-02 Sacituzumab Govitecan Effective in Hormone Receptor–Positive, HER2-Negative Metastatic Breast Cancer
For advanced breast cancer that is hormone receptor–positive and HER2-negative, sacituzumab govitecan-hziy significantly reduced the risk of disease progression by 34% over physician’s choice of treat...
Jul 5, 2022
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Dose up on Instagram‎: "👇🏻👇🏻👇🏻 🎗️ سرطان الثدي الإيجابي لـ HER2 ودور Trastuzumab مريضة مشخصة بسرطان ثدي يتميّز بفرط تعبير HER2 (Human Epidermal Growth Factor Receptor 2)، وهو نمط يرتبط بسلوك عدواني ومعدل نكس أعلى في حال عدم المعالجة النوعية. في هذه الحالات، يُعد العلاج الموجّه حجر الأساس في الخطة العلاجية. 🔬 الآلية الجزيئية للمرض: مستقبل HER2 هو مستقبل تيروزين كيناز يشارك في تنظيم نمو الخلايا وانقسامها. فرط التعبير عن HER2 يؤدي إلى تنشيط دائم لمسارات التكاثر الخلوي وزيادة خباثة الورم. 💉
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Dose up on Instagram‎: "👇🏻👇🏻👇🏻 🎗️ سرطان الثدي الإيجابي لـ HER2 ودور Trastuzumab مريضة مشخصة بسرطان ثدي يتميّز بفرط تعبير HER2 (Human Epidermal Growth Factor Receptor 2)، وهو نمط يرتبط بسلوك عدواني ومعدل نكس أعلى في حال عدم المعالجة النوعية. في هذه الحالات، يُعد العلاج الموجّه حجر الأساس في الخطة العلاجية. 🔬 الآلية الجزيئية للمرض: مستقبل HER2 هو مستقبل تيروزين كيناز يشارك في تنظيم نمو الخلايا وانقسامها. فرط التعبير عن HER2 يؤدي إلى تنشيط دائم لمسارات التكاثر الخلوي وزيادة خباثة الورم. 💉
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