Homepage | RMD Open | A leading rheumatology journal from …
RMD Open. is an open access, peer-reviewed rheumatology journal that publishes original research on rheumatic and musculoskeletal disorders and connective tissue diseases. RMD Open publishes high quality peer-reviewed original research covering the full spectrum of musculoskeletal disorders, rheumatism and connective tissue diseases, including ...
The osteocyte: key player in regulating bone turnover - RMD Open
Throughout postnatal life bone undergoes continuous structural reorganisation and adaptation. The adaptive process is dependent on the coordinated activity of osteoclasts and osteoblasts that form a so called bone multicellular unit (BMU) that remodels cortical and trabecular bone through a process of osteoclast-mediated bone resorption, followed by …
Imaging of diffuse idiopathic skeletal hyperostosis (DISH) - RMD …
Diffuse idiopathic skeletal hyperostosis (DISH) is a condition characterised by calcification and ossification of ligaments and entheses. The condition usually affects the axial skeleton, in particular, at the thoracic segment, though also other portions of the spine are often involved. DISH often involves also peripheral tendinous and/or entheseal sites either alone, or in association with ...
This study aimed to systematically collate and discuss treatment options in SAPHO. Methods Following ‘Preferred Reporting Items for Systematic Reviews and Meta- Analyses’ guidance, a systematic literature search was conducted using PubMed, …
VEXAS syndrome: a diagnostic puzzle - RMD Open
The VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is an adult-onset systemic autoinflammatory condition that is caused by an acquired deficiency of the UBA1 gene in hematopoietic progenitor cells. The clinical spectrum of the VEXAS syndrome currently comprises a broad range of phenotypes such as vasculitis, relapsing polychondritis and Sweet’s syndrome. In the ...
Reactive arthritis after SARS-CoV-2 infection - RMD Open
SARS-CoV-2 has been recognised as a potential trigger of inflammatory arthritis in individuals with inflammatory rheumatic diseases as well as in previously unaffected individuals. However, new-onset arthritis after COVID-19 is a heterogeneous phenomenon that complicates differential diagnosis. For example, acute arthritis with features of viral arthritis has been reported after COVID-19, as ...
Recommendations for physical activity and exercise in persons …
Objective This international task force aimed to provide healthcare professionals and persons living with systemic lupus erythematosus (SLE) with consensus-based recommendations for physical activity and exercise in SLE. Methods Based on evidence from a systematic literature review and expert opinion, 3 overarching principles and 15 recommendations were agreed on by Delphi consensus. Results ...
Authors | RMD Open | A leading rheumatology journal from …
Authors. RMD Open is an online-only open access journal dedicated to publishing research on musculoskeletal disorders, rheumatism and connective tissue diseases, including osteoporosis, spine and rehabilitation. The journal aims to provide rapid publication of research through a continuous publication model.
Health technology assessment: a framework - RMD Open
In a time where there is growing pressure on healthcare budgets, there is increased scrutiny of new health technologies, their effectiveness, safety and costs.1 It is in this context that Health Technology Assessment (HTA) has become increasingly important. The purpose of HTA is to provide policymakers with evidence to inform decision-making and develop guidance on the reimbursement and ...
Biologicals in rheumatoid arthritis: current and future - RMD Open
The aim of the review is to highlight the current knowledge about established and new biologicals and to summarise recent advances by focusing on comparative efficacy, safety and possible discontinuation of treatment in patients with rheumatoid arthritis (RA). Up to now, comparative analyses showed only minor differences with respect …