Unraveling a key brain chemical, galanin, new research in fish shows it typically calms brain activity. However, stress can weaken this calming effect, leading to overactivity and seizures. This ...

Connexin 41.8 governs timely haematopoietic stem and progenitor cell specification. Haematopoietic stem and progenitor cells ...

The neuropeptide galanin modulates whole-brain activity and stress responses in zebrafish, revealing a complex, receptor-dependent role in seizure regulation with implications for epilepsy, and ...

These findings from KRYSTAL-7 may support future efforts to establish adagrasib as part of a first-line standard of care regimen in KRAS G12C–mutant NSCLC, pending results from the phase 3 trial.

Using a simple zebrafish model of the ultra-rare genetic disease XMEA, researchers were able to test 30 clinically tested drugs and identify 2 that significantly improved XMEA symptoms.

Can a small fish help identify possible treatments for an ultra-rare inherited disease found in an Alabama boy? The genetic disease is XMEA, which progressively weakens the muscles and can affect ...

In a study published in EMBO Molecular Medicine, Alexander and Dowling now show that their mutant zebrafish have weakened muscles and other symptoms that mirror human XMEA disease. With this simple ...

We analyzed the exomes or genomes of infants with suspected monogenic congenital diarrheal disorders. Using cell and zebrafish models, we tested the effects of variants in newly implicated genes.

Previous studies have shown that protein expression of DOCK7 is increased in skeletal muscle biopsies from patients with Duchenne muscular dystrophy (DMD), leading researchers from the University of ...

In vertebrate retinas, specialized photoreceptors responsible for color vision (cone cells) arrange themselves in patterns ...

The mutant zebrafish also showed mild under-development of the neural crest at larval stages. The research determined that in zebrafish the baz1b gene impacts both morphological and behavioural ...