Unraveling a key brain chemical, galanin, new research in fish shows it typically calms brain activity. However, stress can weaken this calming effect, leading to overactivity and seizures. This ...

Connexin 41.8 governs timely haematopoietic stem and progenitor cell specification. Haematopoietic stem and progenitor cells ...

Using a simple zebrafish model of the ultra-rare genetic disease XMEA, researchers were able to test 30 clinically tested drugs and identify 2 that significantly improved XMEA symptoms.

We analyzed the exomes or genomes of infants with suspected monogenic congenital diarrheal disorders. Using cell and zebrafish models, we tested the effects of variants in newly implicated genes.

Zebrafish The key to understanding vertebrate development and the origins of human birth defects may lie with the fishes--that is, with the zebrafishes (Danio rerio). Using zebrafish mutants produced ...

Previous studies have shown that protein expression of DOCK7 is increased in skeletal muscle biopsies from patients with Duchenne muscular dystrophy (DMD), leading researchers from the University of ...

The vma21 mutant zebrafish phenocopy the human disease with impaired motor function and survival, liver dysfunction, and dysregulated autophagy indicated by lysosomal de-acidification, the presence of ...

Researchers from Fudan University and Southwest University published data from a study that detailed the development of a novel vertebrate model suitable for high-throughput screening of potential ...

Heart disease is the leading cause of death worldwide. Despite decades of research, most heart pathologies have limited treatments, and often the only curative approach is heart transplantation. Thus, ...

Conclusions: The present study demonstrates the successful generation of CNTF mutant zebrafish using the CRISPR/Cas9 genome editing technique. Further investigations are necessary to deepen our ...

However, mutant zebrafish genetically altered to silence oxytocin production did not display the same fear behaviors that were displayed by control zebrafish when encountering a distressed shoal.

In summary, 3Z introduced a genetic model of ADHD in zebrafish and identified five novel putative therapeutics. The findings offer a novel tool for understanding ADHD, suggest a novel mechanism for ...