How can scientists better understand the workings of a cell? Studying the transcriptome, RNA expressed from the genome, reveals a more complex picture of the gene expression behind it all.

More information: Jinyang Zhang et al, Real-time and programmable transcriptome sequencing with PROFIT-seq, Nature Cell Biology (2024). DOI: 10.1038/s41556-024-01537-1 Provided by Chinese Academy ...

Low-depth long-read transcriptome sequencing, with only 10,000s of reads per sample, is sufficient to assemble hundreds of highly expressed genes, including all or nearly all mitochondrial ...