One of the most striking features of our world is the continuous cycle of day and night. Almost all living organisms, ...

These rhythms are orchestrated by the suprachiasmatic nucleus (SCN) in the hypothalamus and involve a network of genes, including CLOCK and BMAL1, that influence metabolism, immune responses ...

Within the hypothalamus, dual structures called the suprachiasmatic nuclei (SCN) act as a central clock for the circadian system, setting daily rhythms that in mature individuals are largely ...

Here we demonstrated that the circadian rhythm of SCN electrophysiological activity showed two distinct peaks when slices were cut in the horizontal plane. In horizontal slices, a morning peak ...

This regular pulse was found to act as a kind of chemical metronome, helping to synchronize the neurons of the SCN and so indirectly impacting circadian rhythm and the sleep-wake cycle.

Increasing evidence highlights a bidirectional relationship between circadian disruption and hepatic pathophysiology, suggesting liver disease is both a consequence and a driver of circadian ...

The SCN receives direct input from your eyes about ... This is why maintaining consistent daily routines helps reinforce healthy circadian rhythms and the hormonal patterns that depend on them.

"The SCN is considered our central clock and plays a crucial role ... For example, depending on the rhythm of the heart’s clock, the heart muscle may be particularly efficient at pumping blood during ...