Mutations in the SRSF2, TET2, and RUNX1 genes mark the transition to the blast ... This finding was further supported by the gain of typical de novo acute myeloid leukemia gene mutations, together ...

Of particular interest is the observation that DNMT3A and RUNX1 mutations seem to have a more pronounced ... The high ligand-receptor (LR) scores identified in Acute Myeloid Leukemia (AML) are ...

Researchers from the Tumor Profiler consortium have combined single-cell multi-omics and functional profiling for 21 AML ...

Secondary acute myeloid leukemia (AML) is a blood cancer that arises from other blood disorders or previous cancer treatment. Those with secondary AML tend to have a less favorable outlook than ...

When resistance to or failure of hypomethylating agents (HMAs) occurs in acute myeloid leukemia (AML), depleting a ligase ...

The FDA has granted fast track designation to HC-7366 for the treatment of adult patients with relapsed/refractory acute ...

Researchers sought to determine whether DNA methylation markers could be helpful in risk stratification for patients with AML and normal cytogenetics.

Scientists from Duke-NUS Medical School and their collaborators have identified an inherited genetic variation prevalent ...

THRAP3, STMN1, and GNA13—are overrepresented in blood cancers like acute myeloid leukemia (AML) and could prove to be novel ...

Syndax (SNDX) announced that multiple abstracts evaluating revumenib, an oral small molecule menin inhibitor, have been accepted for oral ...