NFL Week 16 odds, picks, predictions, TV channel, streaming information for Monday Night Football between San Francisco 49ers and Indianapolis Colts.

The 49ers are just one game back of the NFC-leading Los Angeles Rams (11-3) for the conference’s No. 1 playoff seed, but Los Angeles plays the Seattle Seahawks — also 11-3 — in Week 16, so San Francisco won’t be able to claim the top seed in Week 16 since one of those two teams still will have a better record at the end of the week.

SANTA CLARA – Here is how the 49ers (10-4) graded in Sunday’s 37-24 home win over the Tennessee Titans (2-11):

Titans PFF grades reveal the best and worst performers, key snap counts, and standout moments from San Francisco's Week 15 win.

San Francisco 49ers WR Ricky Pearsall put together his best game since reactivation, but his late-game injury to the same knee that shelved him for six weeks is cause for concern.

The home of Tennessee Titans defensive tackle Jeffery Simmons was burglarized while he was on the West Coast to play the San Francisco 49ers this weekend.

Two defensive stars were lost for the season. Their QB missed multiple games. Still, here are the 49ers are, a game out of the No. 1 seed.

The San Francisco 49ers' offense appears finely tuned, but the defense was leaking oil Sunday in a shouldn't-have-been-that-close 37-24 defeat of the two-win Tennessee Titans.