Patients with type 2 diabetes mellitus are at a higher risk of developing heart failure compared with the healthy population. In recent landmark clinical trials, sodium-glucose co-transporter 2 (SGLT2 ...

In this article, we present a design concept, in which a monolithic soft body is incorporated with a vibration-driven mechanism, called Leafbot. We first report a morphological design of the robot's ...

The application of machine learning algorithms to predict the mechanism of action (MoA) of drugs can be highly valuable and enable the discovery of new uses for known molecules. The developed methods ...

Mechanism of action (MoA) ACCase-inhibiting herbicides have specific activity on grasses due to their selective inhibition of homomeric plastidic ACCase which is only found in monocots, with ...

Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action Miniperspective Elena Fernández-Álvaro † , W. David Hong ‡ , ...

Running electricity-thirsty appliances like dishwashers and laundry dryers in the middle of the night is a form of climate action – especially during heat waves like those swamping Michigan in ...

Indianapolis Vision Zero Task Force unveils draft Action Plan to reduce traffic fatalities to zero by 2035.

In this GEN webinar, Dave Lahr, PhD, Senior Director of Bioinformatics at Foghorn Therapeutics, discusses chromatin regulation and epigenetic mechanisms that shape transcriptional responses to ...

The potential of repurposing cipargamin for treating Babesia species offers both theoretical advancements and practical applications in combating parasitic infections.

In contrast to the WHO recommendation to give all HIV- infected children over 12 months of age isoniazid preventive therapy, our results show no effect of isoniazid preventive therapy among this ...

Researchers reported in The New England Journal of Medicine that 4 months of rifampin was noninferior to 9 months of isoniazid for the treatment of adults with latent tuberculosis. The shorter ...

The mechanism of action (MoA) of a clickable fatty acid analogue 8-(2-cyclobuten-1-yl)octanoic acid (DA-CB) has been investigated for the first time. Proteomics, metabolomics, and lipidomics were ...