Annually, the Office of Academic Programs awards multiple $2,000 scholarships to students who demonstrate high academic performance, quality research contributions, and a desire for continued learning ...

"These findings suggest that histone modifications in macrophages not only activate genes involved in the immune response, but that these genes additionally form guanine quadruplex DNA structures ...

These include mutations in genes that encode enzymes that covalently modify histone proteins and/or recognize the modified histone proteins. "Histone modification was implicated in the regulation ...

Figure 1. An overview of epigenetic mechanisms. The basic unit of chromatin is the nucleosome. Two molecules of H2A, H2B, H3, and H4 form a histone octamer, and DNA molecules are coiled around the ...

Discover how to examine and alter histone modification mechanisms to explore the role of epigenetics in health and disease. Singleron Biotechnologies and Hamilton Bonaduz AG today announced the ...

Here, we mainly summarize recent findings on TME-associated epigenetic alterations of tumor-associated macrophages (TAMs), including DNA methylation, posttranslational modifications of histone ...

We performed a genetic screen in Saccharomyces cerevisiae to identify histone mutants that exhibit transcriptional readthrough of terminators. Amino acid substitutions identified by the screen map to ...

1994; Cairns et al., 1996). SWI/SNF chromatin remodelers reposition nucleosomes by translocating DNA around the histone octamer, and in vitro assays have shown that they move nucleosomes to the ends ...

The new findings contradict previous assertions that Ashkenazi mitochondrial lineages originated in the Near East, or from mass conversions to Judaism in the Khazar kingdom, an empire in the north ...

Our hypothesis rests on the central concept that mammalian histone H3 variants (H3.1, H3.2, and H3.3), although remarkably similar in amino acid sequence, exhibit distinct posttranslational ...