Cell Death and Disease

New Understanding of How Genetic Mutation Causes Huntington’s Disease

Study explains long-standing question of why Huntington’s disease symptoms typically do not appear until midlife even though patients are born with the mutation. Analyses reveal that the repeated DNA sequence driving the disease expands slowly over decades in certain brain cells and then rapidly lengthens and kills the cell.

Hosted on MSN · 2d

Surprising way that genetic mutation causes Huntington's disease changes understanding of the disorder

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of brain cells.

The Associated Press on MSN · 2d

Surprise finding sheds light on what causes Huntington's disease, a devastating fatal brain disorder

Scientists are unraveling the mystery of what triggers Huntington’s disease, a devastating and fatal hereditary disorder that strikes in the prime of life, causing nerve cells in parts of the brain to break down and die.

Toxic ‘Forever Chemicals’ Are Everywhere—New Study Has Linked Them to Cell Death in Our Nervous System

The study is particularly significant because it could help explain the association between these plastic-derived chemicals ...

10don MSN

Elucidating the mechanism that prevents cell death caused by uncontrolled nuclear autophagy

Macronucleophagy helps control micronucleophagy to protect yeast cells during stress. Through extensive experiments with ...

Hosted on MSN1d

Study Unveils Surprising Cause of Brain Cell Death in Huntington's Disease

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a ...

devdiscourse2d

Unraveling Huntington's Mystery: A Breakthrough in Genetic Research

Scientists uncover how a genetic mutation linked to Huntington's disease stays harmless for years before expanding and causing cell death. The study discovers that DNA repeats must exceed 150 CAGs to ...

3don MSN

Fatal neurodegenerative disease in kids also affects the bowel

Researchers at Washington University School of Medicine in St. Louis have described the neurodegeneration that occurs in the ...

Science Daily3h

Textbooks need to be rewritten: RNA, not DNA, is the main cause of acute sunburn

Sunburn has traditionally been attributed to UV-induced DNA damage. However, a new study reveals that RNA, another vital cellular molecule, plays a major role in triggering acute sunburn reactions.

The American Journal of Managed Care1d

FDA Grants 2 Traditional Approvals for Acalabrutinib

The Bruton tyrosine kinase inhibitor was approved in combination with bendamustine and rituximab in previously untreated ...

Monthly Prescribing Reference1d

Calquence Combo Therapy Approved for Previously Untreated Mantle Cell Lymphoma

The Food and Drug Administration (FDA) has approved Calquence ® (acalabrutinib) in combination with bendamustine and rituximab for the treatment of adults with previously untreated mantle cell ...

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