Cytogenetic studies of bone marrow should ... Current Status of Treatment for Chronic Myelogenous Leukemia. MedGenMed 2(2), 2000 [formerly published in Medscape Hematology-Oncology eJournal ...

Chronic Myeloid Leukemia (CML) CML ... and KMT2A rearrangements. The use of cytogenetics, FISH, and NGS panels aids in classification, prognostication, and treatment selection.

Table 1. Cytogenetic and molecular response rates of large clinical trials testing first-line high-dose imatinib in chronic-phase chronic myeloid leukemia. Study (year) Trial Response (%) Ref.

So far, technical methods for detecting cytogenetic changes have favored ... A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and ...

As the field of human cytogenetics emerged ... translocation event involving chromosomes 9 and 22 was responsible for CML (Rowley, 1973). G-banding methods continue to be widely used today ...