The skin is the largest organ in the human body. It makes up about 15% of our body weight and protects us from pathogens, ...

Physiological extracellular matrix (ECM) calcification or mineralization is restricted to bones, teeth and the hypertrophic zone of growth plate cartilage. In contrast, pathological ECM ...

Growing cells in the laboratory is an art that humans have mastered decades ago. Recreating entire three-dimensional tissues is much more challenging. Researchers are developing a new hydrogel-based ...

Even simple animals like sponges have these proteins ... The extracellular portion of the integrin then binds to molecules in the extracellular matrix or on the surface of other cells.

Using animal models, we found that when these ... Our team developed "first-in-class" neurofibrosis inhibitors that target the extracellular matrix in the brain. And we discovered that they ...

A comprehensive proteomic map of liver fibrosis progression and healing in two mouse models identifies etiology-specific extracellular matrix components, laying the foundation for targeted ...