The study introduces new tools for measuring the intracellular calcium concentration close to transmitter release sites, which may be relevant for synaptic vesicle fusion and replenishment. This ...

Neuronal degeneration leading to visual impairment or blindness remains a critical challenge in human health. Unlike humans, ...

enhanced the use of the CRISPR-RfxCas13d system in zebrafish for targeted depletion ... is the most common type of inherited retinal dystrophy without effective treatments. Here, authors apply ...

enhanced the use of the CRISPR-RfxCas13d system in zebrafish for targeted depletion of endogenous mRNAs. Retinitis pigmentosa (RP) is the most common type of inherited retinal dystrophy without ...

With the prediction of region-specialized UV cone parallel channels, we suggest the acute zone in the zebrafish retina supports detecting light-off events at high temporal frequencies. This work ...

The preclinical evaluation of drug-induced cardiotoxicity is an important stage in the drug development process; however, traditional methods for screening drug candidates, such as cardiomyocyte-based ...

Treatment shows potential to slow the progression of human degenerative eye diseases, including retinitis pigmentosa.

Inside the human eye, the retina is made up of several types of cells, including the light-sensing photoreceptors that initiate the cascade of events that lead to vision.

Discover how integrating smoking cessation with NHS therapy for depression and anxiety improves quit rates, enhancing both ...