Researchers have successfully employed an algorithm to identify potential mutations which increase disease risk in the noncoding regions our DNA, which make up the vast majority of the human genome.

Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of ...

A seminal study has uncovered a new genetic cause of neurodevelopmental disorders (NDDs). The discovery offers both closure and hope to potentially thousands of families worldwide who have long been ...

University of Delaware's Mona Batish is a molecular biologist. She studies circular RNAs formed as a result of so-called ...

Researchers have identified mutations in the non-coding gene RNU2-2 as a cause of a newly defined neurodevelopmental disorder ...

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

RNA-based therapeutics are gaining traction due ... down the field of targets from tens of thousands (76-96% of the human genome), to just a few dozen viable treatment areas.

yet much of the non-coding genome is transcribed into RNA. Over the past few decades, scientists have discovered that these non-coding RNAs mediate essential functions in healthy cells — and ...

Fusion events can join both coding and noncoding regions ... of low-cost high-throughput sequencing methods including whole-genome sequencing, long-read sequencing, and single-cell RNA sequencing, we ...

are non-coding RNAs with more than 200 nucleotides in length. They act as competing endogenous RNAs (ceRNAs) to regulate post-transcriptional gene stability and modulate protein-protein, protein-DNA, ...

Indeed, advances in technology have revealed that much of the noncoding genome gives rise to lncRNAs and other RNA molecules that affect all manner of cellular processes. “The vast majority of the ...