Using an in vivo model of lymphocyte arrest, we show here that LFA-1-mediated arrest of lymphocytes rolling on high endothelial venules bearing LFA-1 ligands and chemokines was abrupt.

Tumor-infiltrating lymphocyte therapy has been in development for several decades. Preclinical studies evaluating its efficacy began at the National Cancer Institute (NCI) in the early 1980s.