Every organ in our body contains a small number of adult stem cells that are specific to its niche. These cells act like a ...

The basic building blocks of chromatin are nucleosomes, each of which is composed of 146 bp of DNA wrapped around a histone octamer that ... which affect chromatin structure and transcription.

SWI/SNF chromatin remodelers reposition nucleosomes by translocating DNA around the histone octamer, and in vitro assays have shown ... Here, we have used cryo-EM to determine the structure RSC. The ...

ISWI-family nucleosome remodeling enzymes need the histone H4 N-terminal tail to mobilize nucleosomes ... These particles consist of ~150 bp of DNA that wrap almost twice around an octamer of histones ...

would be dictated by the particular histone variant, whereas the potential actions of a specific modifying enzyme(s) depends, in part, on the unique structure of that chromatin fiber that the variant ...