Mapping gene disruptions in sporadic early onset Alzheimer's disease across key brain regions

A new study led by researchers at UTHealth Houston investigated both gene expression and regulation at single cell levels to ...
University of California, San Francisco

Tissue Repair Slows in Old Age. These Proteins Speed It Back Up

UCSF scientists engineered old fibroblast cells to turn their genes on and off in the same way as young fibroblasts. The old ...

An AI-driven strategy to accelerate microbial gene function discovery

We know the genes, but not their functions—to resolve this long-standing bottleneck in microbial research, a joint research ...

First-time use of AI for genetic circuit design demonstrated in a human cell line

There are hundreds of cell types in the human body, each with a specific role spelled out in their DNA. In theory, all it ...
eLife

Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

A new CRISPR-based approach for tuning gene expression up and down allowed identification of how other genes' expression responds to changes of transcription factors.
AlphaGalileo

SIK1: A PROTECTIVE REGULATOR IN EV-D68–INDUCED ASTHMA

New Study Shows SIK1 Strengthens Antiviral Immunity to Limit EV-D68–Induced Asthma Exacerbations Asthma is a chronic ...