Histones not only keep DNA organized, but also help regulate gene expression. How? Scientists are using ChIP and PCR to find out. To examine changes in histone modification during blood cell ...

Every organ in our body contains a small number of adult stem cells that are specific to its niche. These cells act like a ...

So far, a number of histone variants have been found and localized to specific areas of chromatin. For instance, H2A.Z is a variant of H2A and is often enriched near relatively inactive gene ...

One function of histone modifications is to make DNA more or less accessible ... regions that are much more accessible to transcription machinery. 7 “There's chromatin looping, which is the idea that ...

But how exactly does COVID-19 remodel chromatin? One mechanism may be through epigenetic changes. The infected cells were missing an acetyl group—known as H3K27Ac—on their third histone that’s ...

This process begins with their conversion into active metabolites, propionyl-CoA and butyryl-CoA, which are then used as ...

LSD1 is a histone demethylase that plays a significant role in chromatin remodeling and gene expression by modifying histone H3 lysine residues. It interacts with various protein complexes ...

Approximately 50% of chromosomes and chromatin is protein. These include histones, transcription factors, nuclear receptors, co-activators, co-repressors, histone modifying enzymes, nucleosome binding ...

In addition, a host of additional histone chaperone complexes and chromatin remodelers is known to be required for the assembly and maturation of nascent chromatin (Figure 4). Figure 4: ...

Epigenetic changes, including histone modifications and proteome, are critical regulatory mechanisms, involved in all developmental processes including aging and age-associated diseases. The goal of ...

Among these, histone H3 lysine 27 trimethylation (H3K27me3 ... In their latest study, they employed chromatin profiling, transcriptomics, biochemical, and genetic approaches to systematically ...