CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice. Arthritis Rheum. 60 , 123–132 (2009). Article CAS Google Scholar ...
Checkpoint blocking antibodies targeting regulatory molecules on T cells such as CTLA-4 and PD-1 have reinvigorated the ... and a relative reduction in the frequency of regulatory T cells. As in prior ...
SAN DIEGO and SUZHOU, China - Adagene Inc. (NASDAQ: ADAG), a biotechnology firm with a market capitalization of $85 million ...
ADG126, also known as muzastotug, is a novel anti-CTLA-4 SAFEbody® developed by ... The company's lead clinical program, ADG126, targets regulatory T cells in the tumor microenvironment and ...
but when the antibodies against CTLA-4 or PD-(L)1 regulate Tregs, they can cause immune disorders and even serious autoimmune diseases and other side effects. Therefore, the success of clinical ...
Short-course radiotherapy (SCRT) followed by fruquintinib plus adebrelimab and CAPOX in the total neoadjuvant therapy of locally advanced rectal cancer (LARC): A multicenter, single-arm, open-label, ...
News Medical on MSN5d
Microbes in your gut could determine cancer treatment outcomesResearchers reveal that gut microbiota influence the effectiveness of immune checkpoint inhibitors (ICIs) in cancer treatment ...
1Northwestern University, Chicago, Illinois.
Medical Xpress on MSN12d
Regulatory T cells found to safeguard brain health and memory formationImmune cells called regulatory T cells have long been known for their role in countering inflammation. In the setting of ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results
Feedback