CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice. Arthritis Rheum. 60 , 123–132 (2009). Article CAS Google Scholar ...

By blocking inhibitory signals mediated by surface receptors that are naturally upregulated during activation of antigen-presenting cells (APC) and T cells, predominantly PD-1 and its ligand PD-L1, as ...

Researchers reveal that gut microbiota influence the effectiveness of immune checkpoint inhibitors (ICIs) in cancer treatment ...

Holding these trigger-happy troops back during peacetime falls to a sparse population of regulatory T cells, according to a paper published January 28 in Science Immunology. These Tregs are potent.

A subcommittee of the U.S. House of Representatives will hold a hearing on Thursday on how regulatory policy impacts the prevention of natural disasters, with a focus on the deadly wildfires that ...

In fact, given the importance of UBS for the Swiss banking system, regulators may demand from UBS to hold an additional $15-25 billion of capital, equal to 2–4 years of UBS' post 2026 earnings ...

CLEVELAND, Feb. 4, 2025 /PRNewswire/ -- 4AIR, the global leader in business aviation sustainability, today announced that it has launched an integration connection with the flight planning tool ...

The M14TIL trial involved 168 patients with stage 3c to 4 melanoma that was too advanced ... The patient then receives chemotherapy to reduce regulatory T cells that can put a brake on immune ...

AstraZeneca's lengthy and turbulent development of CTLA4 inhibitor tremelimumab has at least led to a regulatory approval as part of a combination therapy for advanced liver cancer. Tremelimumab ...

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