There is a clear need for both disease-modifying agents and alternative analgesic therapies in osteoarthritis. Currently, there are none of the former, and the latter are limited by adverse effects, ...
To explore the change of 5-lipoxygenase (5-LO) pathway expression and proinflammatory mediators level of lung tissue and cerebral cortex, and the possible regulatory mechanism through central nervous ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, No. 15 (Jul. 18, 1995), pp. 6966-6970 (5 pages) We studied the expression of arachidonate 5-lipoxygenase (5-LO ...
SRI International has divulged lipoxygenase inhibitors, particularly polyunsaturated fatty acid 5-lipoxygenase (ALOX5) and/or ALOX15, reported to be useful for the treatment of bacterial infections.
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