Over the long term, the Li lab is highly interested in pursuing the GARP:TGF-beta pathway as a potential therapeutic target to treat autoimmune diseases.

The USP15 protein has been identified as novel target for therapy against cancer progression, investigators report. In certain settings, the TGF-beta pathway can act as an oncogene, enhancing ...

Why context is key for TGF-Beta's role in cancer metastasis The study brings together two longstanding areas of research for the Massagué Lab: TGF-beta signaling and metastasis.

The mice upregulated extracellular matrix (ECM) proteins and the ECM upstream regulator TGF-β1 (image above). Spinal cord, but not cortical, neurons contained 50 percent more of the type VI collagen ...

Over the long term, the Li lab is highly interested in pursuing the GARP:TGF-beta pathway as a potential therapeutic target to treat autoimmune diseases.

Led by researchers at Baylor College of Medicine, the team of scientists found that the Transforming Growth Factor beta (TGF-beta) signaling pathway in uterine cells protects against the disease by ...

When it comes to cancer metastasis, it takes two to tango. That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS ...

Transforming growth factor beta 1 (TGFB1), also known as TGF-β1, CED, DPD1, and TGFB, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted ...

The tumor microenvironment (TME) constitutes the tumor, extracellular matrix (ECM) and several non-transformed cells, such as immune infiltrates, fibroblasts and vascular vessels recruited from ...

Researchers have identified a pathway that regulates B cell tolerance -- two proteins, GARP and TGF-beta, interact to temper B cell activity, thereby regulating autoimmunity.