The findings suggest that APC-deficient cells rely on ALDH2 to manage metabolic stress, making them particularly vulnerable when this pathway is disrupted. In contrast, cells with intact APC function ...

A team of researchers at the University of Cologne’s Center for Biochemistry, together with the Bambino Gesù Pediatric Hospital in Rome, Italy, have discovered a fundamental biological mechanism that ...

Vitamin B2 metabolism supports cellular defenses against ferroptosis, a form of cell death. Limiting this pathway increases ...

This finding, he suggests, helps link the study of cell death in the worm and oncogenesis in people. "There were a number of papers that had suggested a relationship between cell death and oncogenesis ...

Selective ASO-based JAK2 inhibitor for the treatment of hematological malignancies with JAK2 V617F mutation burden. Use of causal modeling to uncover cell-cell communication dynamics in the tumor ...

Cells have the remarkable ability to initiate their own death through a mechanism called programmed cell death, also known as apoptosis. Apoptosis contains sophisticated signalling pathways and ...

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC ...

How did cells evolve a process to end their own lives? Recent research suggests that apoptosis, a form of programmed cell death, first arose billions of years ago in bacteria with a primitive ...

Researchers at the University of Michigan have revealed that cells use a previously unknown feat of molecular craftsmanship ...

There are several programmed cell death pathways that lead to cellular self-destruction, either for developmental processes, tissue maintenance, or stress responses. These include apoptosis, ...