National Academies of Sciences%2c Engineering%2c and Medicine

Toward Sequencing and Mapping of RNA Modifications

RNA plays critical roles in nearly all biological processes, but current methods for sequencing RNA are significantly limited. This is partially because RNA molecules are chemically modified within ...
Baylor College of Medicine

Researchers show benefit of ultra-deep RNA sequencing in Mendelian disorder diagnostics

RNA sequencing (RNA-seq) is a powerful tool in diagnosing Mendelian disorders, but the optimized sequencing depth for this technology has not yet been determined. In a new study published in the ...
Baylor College of Medicine

Baylor researchers develop and validate clinical diagnostic RNA sequencing test

RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at ...
EurekAlert!

Genome Research publishes a Special Issue on Long-read DNA and RNA Sequencing Applications in Biology and Medicine

November 20, 2024 – Genome Research (https://genome.org) publishes a special issue highlighting advances in long-read sequencing applications in biology and medicine. In this first of two Special ...
EurekAlert!

Singapore scientists unveil one of world’s largest long-read RNA sequencing datasets to advance disease research

SG-NEx provides an open-access resource for the global research community, accelerating biomarker discovery and precision medicine through: Singapore – A team of scientists led by the A*STAR Genome ...
HealthTech

Perturb-Seq in Practice: Dissecting Gene Function with CRISPR + scRNA-Seq

In modern functional genomics, understanding how specific genes control cellular behavior requires both targeted intervention and high-resolution analysis. That’s where Perturb-Seq comes in—a method ...