The Y chromosome is among the smallest in the human body and carries the fewest genes. Researchers are paying renewed attention to its role in cancer—specifically, what happens when it vanishes.

New research shows that the male X chromosome is silenced in some types of cancer. Researchers evaluated how a certain gene affects the male X chromosome in cancer cells. Experts explain why these new ...

Loss of the Y chromosome in aging men is widespread and increasingly linked to serious diseases, challenging assumptions that ...

The loss of the Y chromosome in tumour cells is linked to poor outcomes for people with cancer 1, but this genetic alteration might also compromise immune cells that would otherwise fight the disease.

Altogether, the researchers found that 38% of the X chromosome genes in the two cell types that they tested are affected by the presence of inactive X chromosomes, either because the genes are ...

Researchers at the Johns Hopkins Kimmel Cancer Center and its Ludwig Center uncovered new evidence that extra copies of a ...

Robertsonian chromosomes are large chromosomes that form when the long arm of a chromosome breaks and fuses with another chromosome. They are the most common type of chromosome rearrangement in humans ...

"Inter-chromosome connections may prove to be an integral and pervasive governing feature of chromosome organization in many types of human cells," says Stowers Investigator Jennifer Gerton, Ph.D., ...