Transcription factors are a class of proteins that interact with DNA to regulate gene expression. They’re also implicated in many cancers. For years, scientists have considered transcription factors ...

The establishment and maintenance of neuronal identity are critically dependent on a finely tuned interplay between transcription factors and the epigenetic landscape. Central to this network is the ...

Northwestern Medicine scientists have discovered how molecular "traffic controllers" in cells influence aging and cellular senescence—a state where cells stop dividing but remain metabolically active.

Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...