Dysregulation of splicing, an emerging cause of many neurological disorders, affects all aspects of neurobiology from neurogenesis to synaptic function. The interplay between polypyrimidine tract ...

Shown is the splicing pathway. The pre-messenger RNA (pre-mRNA) has exons (blue) and introns (pink). The spliceosome (not shown) was known to catalyze two chemical reactions (black arrows) in a ...