Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...
The small guanosine triphosphatase Ran loaded with GTP (RanGTP) can stimulate assembly of the type V intermediate filament protein lamin B into a membranous lamin B spindle matrix, which is required ...
Robert Blackwell, Christopher Edelmaier, Oliver Sweezy-Schindler, Adam Lamson, Zachary Gergely, Eileen O’Toole, Ammon Crapo, Loren Hough, J. Richard McIntosh ...
Mechanistic model for MTOC maturation in GV oocytes. The MTOC (grey) activates near the oocyte cortex, which requires recruitment of CKAP5 and TACC3. After activation, MTOC migrates to the nuclear ...
The central spindle consists of a set of microtubule bundles in anaphase cells that overlap for a short region at their plus ends. The central spindle regulates cleavage furrow formation and ...
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