Ascletis Pharma has reported positive topline Phase III results showing that denifanstat (ASC40), a first-in-class oral FASN inhibitor for moderate-to-severe acne, delivered a favorable long-term ...

Zoe D. Draelos, MD, from Duke University, notes that clascoterone cream's unique sebum reduction mechanism provides effective, highly tolerable, and core acne treatment. The first episode of the ...

HONG KONG, Jan. 29, 2026 /PRNewswire/ -- Ascletis Pharma Inc. (HKEX: 1672, "Ascletis") today announced positive topline results from the Phase III open-label study (NCT06248008) evaluating denifanstat ...

Here's what dermatologists have to say.

Denifanstat showed tolerability and a favourable safety profile and most TEAEs were mild or moderate.

Sagimet Biosciences dropped 9% after Ascletis Pharma’s Phase 3 Denifanstat safety data focused on tolerability, not new efficacy, spurring investor caution. SGMT’s Denifanstat, a first-in-class FASN ...

Cutibacterium acnes, a crunchy Cheeto-shaped bug that lives on human skin, loves the oily pocket around hair follicles. No face is quite as greasy as that of adolescents, flooded with hormones that ...

Sebum is the number one enemy of human skin. That’s what dermatologist Dr. Rachael Eckel of The Skin Health Institute in Trinidad and Medical Advisor for ZO Skin Health believes, since excess sebum is ...

Struggling with acne and pigmentation? Discover expert-recommended tips, skincare habits, and treatments to reduce dark spots ...

Learn more about what causes acne in humans and how it can sometimes impact animals, too.

Unlike teenage breakouts, which are mainly driven by hormonal fluctuation, the causes of adult acne are more complex and ...