Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based ...

A new CRISPR-based approach for tuning gene expression up and down allowed identification of how other genes' expression responds to changes of transcription factors.

Northwestern Medicine scientists have discovered how molecular "traffic controllers" in cells influence aging and cellular senescence—a state where cells stop dividing but remain metabolically active.

The SWI/SNF Ig-Fold for Transcription Factor Interactions or 'SWIFT' domain on mSWI/SNF chromatin remodeling complexes engage ...

A new study led by researchers at UTHealth Houston investigated both gene expression and regulation at single cell levels to reveal disruptions in gene function in three brain regions of patients with ...

Using genomic and transcriptional data has greatly improved the understanding of multiple aspects of human physiology. A new paper in PNAS reports on molecular-level associations of co-occurring ...

Vitamin C is a key nutritional component in fruits, yet its concentration often changes dramatically as fruits develop.

Different variants of a gene, known as isoforms, can be transcribed and translated at varying levels within a cell or tissue. These isoforms are commonly a result of alternative splicing, which ...