A major factor in coronavirus disease 2019 (COVID-19)-associated mortality is the development of coagulation abnormalities that may result in thromboembolism. Human platelets have been found by ...

Researchers have identified serine threonine kinase 10 as a key regulator of platelet function, haemostasis and ...

Diminished platelet autophagy potentially contributes to thrombocytopenia in cirrhotic patients. H 2 S modulates platelet autophagy and functions possibly via the PDGFR-α/PI3K/Akt/mTOR signaling ...

Ado-trastuzumab emtansine (T-DM1) treatment results in grade 3-4 thrombocytopenia in 8%-13% of patients. Prior in vitro studies reported T-DM1 inhibition of megakaryocyte maturation as the cause of ...

The 5' nucleotidase protein apyrase is found in the saliva of all blood feeding arthropods (and an analogue in Vampire bats and leeches). Apyrases are enzymes that degrade ATP and ADP to AMP and ...

A novel score of platelet reactivity expression appears promising for detecting hyperreactivity in patients at increased risk for cardiovascular events, potentially allowing clinicians to better ...

Megakaryocytes, which are derived from hematopoietic stem cell precursors in bone marrow, form and release platelets; these circulate in the blood for 8 to 10 days before they are removed by hepatic ...

Platelets are circulating cell fragments known to clump up and form blood clots that stop bleeding in injured vessels. Cardiologists have long known that platelets can become "hyperreactive" to cause ...