Migrating cells must determine where to form a front end and a back end. A gradient in contact sites between the cell membrane and an organelle called the endoplasmic reticulum (ER) is generated by a ...

Synthetic hydrogel-based assay to study 3D confined cell migration. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adm9195 Eukaryotic cells—that is, cells with a nucleus—possess an astounding ...

Scientists have discovered that cells can sense far beyond the surfaces they touch. While individual cancer cells can probe about 10 microns ahead by tugging on surrounding collagen fibers, clusters ...

Human cells can possibly sense far beyond surfaces they touch, with cancer cells being able to probe about 10 microns ahead, ...

Shootin1b and the adhesion molecule transmit weak traction forces which is well-suited for rapid cell migration, presenting a potential target for preventing spread of glioblastoma. "By suppressing ...

Immune responses rely on the efficient movement of immune cells within the complex and geometrically unpredictable three-dimensional tissues that make up our bodies. Subscribe to our newsletter for ...

“Why are the cells growing there?” Why, indeed. Why would cancer cells migrate to the spinal fluid, far from where they’d been birthed, and how did they manage to thrive in a liquid so strikingly poor ...

How do cells move from A to B through our body to build functional tissues? And how is this process regulated? The answers to these questions are essential – for example, for our understanding of how ...

Using mouse incisor models, researchers reveal how coordinated cell movements form crack-resistant enamel in teeth ...

The gastrointestinal tract is the biggest immune organ in mammals. The gut extends its influence all over the body through various links like the gut-liver axis, the gut-lung axis, and the gut-brain ...