In SetPoint you need to set the buttons to key presses that you don't use when you're playing. Like N, J, K, L, ;, etc. You can either do this for all applications, or figure out which .exe is running ...
Logitech G makes a lot of solid gaming peripherals, but many of their gaming mice and keyboards are definitely guilty of being on the expensive side. If you're not looking to spend $100 on a wireless ...