In a new and improved in vitro model of the blood-brain barrier, scientists allow a milieu of cells to grow together and form multicellular structures. A series of rodent experiments showed that even ...

Using an innovative in vitro model of the blood-brain barrier, Dennis Grab of Johns Hopkins University and his colleagues found that Trypanosoma brucei gambiense requires calcium ions and cysteine ...

After some high-profile crashes, the one-time biotech darling is inching toward success with its Hunter syndrome treatment, which today began a rolling BLA for accelerated approval.

For decades, bypassing the blood-brain barrier has been the challenge facing ... Complementary in vitro experiments used human brain cell models to replicate BBB crossing under controlled conditions.

Oregon State University researchers have discovered a way to get anti-inflammatory medicine across the blood-brain barrier, ...

The blood–brain barrier (BBB) is meant to protect the brain from noxious agents; however, it also significantly hinders the delivery of therapeutics to the brain. Several strategies have been ...

Advances in nanotechnology have shown that nanoparticles can cross this barrier, opening new possibilities for treating brain disorders ... Endothelial cells form the core, lining the cerebral blood ...

Getting therapeutic drugs past the blood-brain barrier has long been a major challenge in treating brain diseases. Now, researchers have explored how cholesterol-modified heteroduplex oligonucleotides ...

Exosomes may significantly contribute to blood-brain barrier dysfunction in children with obstructive sleep apnea (OSA), particularly those with neurocognitive deficits.