Marvel has provided plenty of answers to the question of who can take down the Hulk, and these foes often go beyond simply ...
A berserker Mark Ruffalo attempting to attack an enemy while in full Hulk rage mode sounds like a very MCU-style gag. There's also a legitimate storytelling reason for introducing a new weakness ...
Brave New World gives lots of attention to the fiery effects of the Red Hulk transformation, but never properly explains it.