Each nucleosome consists of approximately 147 base pairs of DNA wrapped around a histone octamer which is composed of two H2A-H2B dimers and one H3-H4 tetramer.

In collaboration with the Zhanxin Wang (Beijing Normal University) and Or Gozani labs, we have solved the cryo-EM structures of NSD2 and NSD3 bound to mononucleosomes, causing unwrapping of the DNA ...

Now, researchers from Kyushu University have demonstrated that the histone modification H3K4me3 in mature mouse oocytes is directly involved in chromosome and spindle stabilization and is crucial ...