Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment has been the focus of a 30-year research question. New work from the Crick ...

Every time a cell divides, it must accurately copy its entire genetic instruction manual. Before this process can begin, cells load their DNA-copying motor—a complex of six subunits known as the ...

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event for DNA to be the molecule that codes all life. A new study from King ...

Brandt Eichman and Walter Chazin, professors of biochemistry, have worked together to provide a better understanding of how exactly DNA replication is initiated in eukaryotes. Using Vanderbilt's state ...

Faithful replication of the genome is essential for development, tissue homeostasis and prevention of malignancy. Key steps in eukaryotic DNA replication include the licensing of replication origins, ...