Harvard University researchers at the Broad Institute report that expansion in situ genome sequencing (ExIGS) linked nuclear abnormalities to hotspots of aberrant chromatin regulation, potentially ...

New imaging tools reveal how within an hour of infection, the virus begins to alter our chromosomes to kick-start its own replication.

Cells depend on the precise reading of DNA sequences to function correctly. This process, known as gene expression, ...

Inside the nucleus of a cell, the chromatin fiber interacts with itself to condense into a chromosome. The chromatin fiber also supports gene expression and replication of chromosomal DNA.

Cells depend on the precise reading of DNA sequences to function correctly. This process, known as gene expression, ...

The common conception of DNA is in long, twisting strands, but in order to fit into the confines of the nucleus, DNA actually condenses into a strict structure called chromatin. Chromatin facilitates ...

Inside a nucleus, chromosomes jumble together like a game of Twister. This can bring regulatory elements, such as enhancers, from one chromosome into contact with genes from another chromosome, ...

To overcome the problem of visualizing chromatin in an intact nucleus, O'Shea's team screened a number of candidate dyes, eventually finding one that could be precisely manipulated with light to ...

There is more movement in our genome than we think. Almost half of the human genome consists of transposons—short DNA ...

But archaea do not have a nucleus, and their small circular genomes are easier to package inside their cells. “If the primary role for chromatin is not packaging, it might instead be to regulate gene ...