Under the microscope in its extended form, chromatin looks like beads on a string. The beads are called nucleosomes. Each nucleosome is made of DNA wrapped around eight histone proteins that ...

Histones not only keep DNA organized, but also help regulate gene expression. How? Scientists are using ChIP and PCR to find out. To examine changes in histone modification during blood cell ...

Northwestern Medicine scientists have uncovered new details about the genetic structure of ovarian cancer stem cells, ...

But how exactly does COVID-19 remodel chromatin? One mechanism may be through epigenetic changes. The infected cells were missing an acetyl group—known as H3K27Ac—on their third histone that’s ...

In a preprint uploaded to bioRxiv this January that has yet to undergo peer review, the team describes hundreds of potential histone proteins in bacteria, including one that they predict interacts ...

A team led by Professor Kazuhiro Maeshima of the National Institute of Genetics (ROIS) and SOKENDAI in Japan has developed a ...

LSD1 is a histone demethylase that plays a significant role in chromatin remodeling and gene expression by modifying histone H3 lysine residues. It interacts with various protein complexes ...

In addition, a host of additional histone chaperone complexes and chromatin remodelers is known to be required for the assembly and maturation of nascent chromatin (Figure 4). Figure 4: ...

Approximately 50% of chromosomes and chromatin is protein. These include histones, transcription factors, nuclear receptors, co-activators, co-repressors, histone modifying enzymes, nucleosome binding ...

Epigenetic changes, including histone modifications and proteome, are critical regulatory mechanisms, involved in all developmental processes including aging and age-associated diseases. The goal of ...

Among these, histone H3 lysine 27 trimethylation (H3K27me3 ... In their latest study, they employed chromatin profiling, transcriptomics, biochemical, and genetic approaches to systematically ...