Genome-wide chromatin accessibility profiling reveals how myelodysplastic syndrome (MDS) stem cells progressively lose normal stem-cell features and acquire myeloid progenitor-like characteristics.

Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) have identified key changes to both chromosome structure and gene expression that affect stem cell function during aging. Using ...

Every cell in a body contains the same genetic sequence, yet each cell expresses only a subset of those genes. These cell-specific gene expression patterns, which ensure that a brain cell is different ...

On the left is a snapshot of single histone molecules (red) inside a cell nucleus (dotted line). On the right, we see the trajectories of these molecules’ movement over time. The colors show the path ...

A study described the three-dimensional architecture of turtle genomes, which fold in a configuration unlike any other animal observed so far. In their long strings of nucleotides, DNA molecules hold ...