The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's ...

Heat shock proteins (HSPs) and molecular chaperones are fundamental to cellular proteostasis, ensuring proteins achieve and maintain their functional conformation while preventing misfolding and ...

Researchers from the Keck School of Medicine of USC used imaging techniques to study how the protein GRP78 controls cancer cell behavior. In the top row, human lung cancer cells were engineered to ...

Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control ...

A new study has found that treatment with a ‘chemical chaperone’ assists in reducing the accumulation of protein plaques and restores cognitive functioning in mouse models of Alzheimer’s disease. The ...

Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis (ALS) affect millions of people worldwide, yet treatments remain largely limited to symptom ...

(L to R) Corresponding author Charalampos Babis Kalodimos, PhD, St. Jude Department of Structural Biology chair, and co-first authors Ziad Ibrahim and Youlin Xia, St. Jude Department of Structural ...