Researchers discover L1td1 maintains stem cell pluripotency by degrading totipotency-associated RNAs

A new study has found that L1td1, a protein evolutionarily co-opted from the Long interspersed nuclear element 1 (LINE1) ...
eLife

SETDB1 enables development beyond cleavage stages by extinguishing the MERVL-driven two-cell totipotency transcriptional program in the mouse embryo

Conditional genetics and single-embryo RNA-seq show that SETDB1 extinguishes the transient, retroelement-driven transcriptional programs of the totipotent two-cell state to facilitate the exit from ...
EurekAlert!

Hmgn3 is critical for inducing totipotency in mouse embryonic stem cells

Mouse embryonic stem cells (ESCs) have emerged as ideal tools for developmental biology research due to their characteristics such as unlimited proliferation and pluripotent differentiation potential.
Mirage News

L1td1 Key to Stem Cell Pluripotency: RNA Breakdown

A new study has found that L1td1, a protein evolutionarily co-opted from the Long interspersed nuclear element 1 (LINE1) ...