G protein-coupled receptors, or GPCRs, sit in the plasma membrane, the boundary that defines the inside and outside of a ...

New research combines two powerful imaging techniques to study the complete structure of a common aGPCR, including how its long and complex extracellular region interacts with the transmembrane region ...

All cells, whether big or small, short or long, rely on proteins to function properly. In most cells, transporting these ...

Researchers say findings may have relevance to understanding cell biological pathways that contribute to nerve repair after ...

Triggering receptors expressed on myeloid cells (TREMs) are a cell surface receptor family found on granulocytes, monocytes, macrophages, and dendritic cells—as well as other myeloid cells in general.

HIV-1 remodels the spatial organization of its co-receptor, CXCR4, on T cell membranes, showing that viral entry requires receptor clustering rather than simple receptor binding.

Adhesion G protein-coupled receptors have a large extracellular region (shown in green and orange) that extends into space outside the cell. Almost 35% of drugs approved by the Food and Drug ...