In the earliest stages of life, mammalian embryos start as a disorganized cluster of cells. As development progresses, these cells become organized into well-defined shapes and structures. This ...
ESPRESSO (Environmental Sensors Phenotyping Relayed by Subcellular Structures and Organelles) combines live-cell fluorescent dyes, hyperspectral microscopy, image processing and data analysis to relay ...
Dysfunctions of the tiny cell processes (primary cilia) of the pancreatic beta cells could be a cause of type 2 diabetes. Little is known about the structure and function of these cilia. An ...
T-cell receptor (TCR) structures are currently under-utilised in early-stage drug discovery and repertoire-scale informatics. Here, we leverage a large dataset of solved TCR structures from Immunocore ...
Researchers have profiled the molecular structure and features of a key part of the deadly Nipah virus. Experiments in cells showe how changes in the viral polymerase -- a protein involved in viral ...
Biomedical research typically follows a familiar path: developing treatments that block, enhance or mutate certain signaling pathways, genes or proteins to change the function of different cells in ...
The design of synthetic developmental programs for multicellular mammalian systems is a cornerstone of synthetic biology. The programs hinge on the construction of gene regulatory circuits that ...
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