Missing DNA replication step revealed in first image of pre-initiation complex

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...
Phys.org

DNA replication in early embryos differs from previous assumptions, study shows

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...
Nature

Control of DNA replication in vitro using a reversible replication barrier

A major obstacle to studying DNA replication is that it involves asynchronous and highly delocalized events. A reversible replication barrier overcomes this limitation and allows replication fork ...
Nature

DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins

Single-stranded DNA-binding proteins (SSBs) protect transiently exposed ssDNA, yet how DNA polymerase (DNAp) displaces them during replication remains unclear. Using single-molecule force spectroscopy ...