Janelia researchers developed an innovative new technique – cycleHCR -- that uses a novel DNA barcode system to track hundreds of RNA and protein molecules in single cells within thick biological ...

In the microscopic world of bacteria, gene transfer is a powerful mechanism that can alter cellular function, drive antibiotic resistance and even shape entire ecosystems. Now an interdisciplinary ...

Nucleic acid-based therapeutics, including antisense oligonucleotides (ASO), small interfering RNA (siRNA), messenger RNA (mRNA), immunomodulatory DNA/RNA, and gene-editing guide RNA (gRNA), hold ...

The approach could expand understanding not only of the layout of elaborate networks in the brain, but also how the brain functions, what happens when there is dysfunction and how neurodegenerative ...

Stay up to date on the latest science with Brush Up Summaries. Article reviewed by Ninning Liu, PhD from the Wyss Institute at Harvard University. Similar to retail stores that use standardized ...

While bulk sequencing quickly became the preferred method, scRNA-seq has increased in popularity in the last decade. In 2015, just 6 % of RNA-seq papers used single-cell methodologies. By 2025, the ...

UC Vice President for Research Patrick Limbach is a key figure in the National Academies’ massive undertaking to sequence RNA in the next 15 years. A chemist who leads the University of Cincinnati’s ...

A new study combines RNA origami and glass nanopores to achieve a 18-nucleotide resolution for diagnosing repeat expansion disorders like ALS.