Johns Hopkins biomedical engineers tracked thousands of neural connections to identify 28 distinct types of dopamine neurons ...

"When engineering a computer, you need to know the circuitry of the central processing unit. If you don't know how everything is wired together, you can't understand its function, optimize it or fix ...

Janelia researchers developed an innovative new technique – cycleHCR -- that uses a novel DNA barcode system to track hundreds of RNA and protein molecules in single cells within thick biological ...

The approach could expand understanding not only of the layout of elaborate networks in the brain, but also how the brain functions, what happens when there is dysfunction and how neurodegenerative ...

A new pathology tool created at Yale harnesses barcode technology and shows potential for use in cancer diagnoses. The technology, Patho-DBiT (pathology-compatible deterministic barcoding in tissue), ...

Comingling RNA barcodes, each correlating to a neuron, indicate where neurons connect in the brain, letting researchers map neural connection with speed, scale and resolution.

Genes have to be expressed in the right place, at the time, and at the right levels to carry out the right functions. To learn more about these physiological processes and how they change in disease, ...

Nucleic acid-based therapeutics, including antisense oligonucleotides (ASO), small interfering RNA (siRNA), messenger RNA (mRNA), immunomodulatory DNA/RNA, and gene-editing guide RNA (gRNA), hold ...

Several ambitious brain connectome projects are underway to diagram the wiring of animals’ most complicated organ. For the most part, neural cartographers rely on microscopy, but tracing numerous ...