Therapeutic antibodies are among the most widely used biologic medicines, yet detecting subtle structural differences in these complex proteins remains challenging. Researchers in Japan have ...

Monoclonal antibodies are among the most widely used biologic medicines, with applications ranging from cancer treatment to autoimmune disease therapy. However, during manufacturing, storage, or ...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomic surveillance has revealed thousands of alterations in structural and non-structural proteins. However, by the end of 2020, viral ...

A new study shows how the single-molecule organization of receptors in a cellular context determines the function of antibodies, opening up new pathways for the development of cancer immunotherapies.

Antibodies, also known as immunoglobulins, are specialized proteins produced by the immune system to identify and neutralize foreign invaders, such as viruses, bacteria, and other pathogens. They are ...

The lower hinge of immunoglobulin G (IgG), an overlooked part of the antibody, acts as a structural and functional control hub, according to a study by researchers at Science Tokyo. Deleting a single ...

Antibody humanization involves modifying antibodies from non-human sources, such as mice, to decrease their immunogenicity in human applications. While mouse monoclonal antibodies are specific, they ...

b) an Fc domain comprising amino acid substitutions M428L/N434S as compared to a human Fc polypeptide, wherein numbering is according to the EU index of Kabat, wherein said anti-C5 antibody with said ...