As a result of this reversible, fluorogenic binding, researchers can visualize extracellular matrix structure in live tissues and animals without interfering with native biological processes.

Even simple animals like sponges have these proteins ... The extracellular portion of the integrin then binds to molecules in the extracellular matrix or on the surface of other cells.

Using animal models, we found that when these ... Our team developed "first-in-class" neurofibrosis inhibitors that target the extracellular matrix in the brain. And we discovered that they ...

A comprehensive proteomic map of liver fibrosis progression and healing in two mouse models identifies etiology-specific extracellular matrix components, laying the foundation for targeted ...

Physiological extracellular matrix (ECM) calcification or mineralization is restricted to bones, teeth and the hypertrophic zone of growth plate cartilage. In contrast, pathological ECM ...