Researchers at the University of Pennsylvania have identified a protein that may play a central role in how Parkinson’s disease spreads through the brain. Their findings suggest that blocking this ...

Key proteins implicated in neurodegenerative diseases are alpha synuclein and tau. Tau aggregation into neurofibrillary tangles, along with amyloid-beta aggregation into plaques, is a hallmark of ...

Amsterdam, NL, November 13, 2019 - Aggregates of the protein alpha-synuclein arising in the gut may play a key role in the development of Parkinson's disease (PD). Investigators are testing the ...

Studies have uncovered that abnormalities in the alpha-synuclein protein are likely a causal factor for numerous diseases, including Parkinson’s disease, multiple system atrophy (MSA), dementia with ...

Skin biopsies detected phosphorylated alpha-synuclein in a high proportion of people with Parkinson's disease and other synucleinopathies. Finding a reliable diagnostic biomarker for synucleinopathies ...

Scientists have carried out an extensive study of a newly discovered mutation that can uncover new insights into the molecular basis of pathology formation in a family of disorders that includes Lewy ...

Researchers identify GPNMB as a driver of Parkinson’s disease spread and demonstrate that monoclonal antibodies can block its activity to slow neurodegeneration.

Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by the aggregation of alpha-synuclein in the brain. Now, scientists have developed a radioligand that facilitates the ...